Class: NMDA_Receptor

•owl:Thing
        •bfo:Entity
                •snap:Continuant
                        •snap:IndependentContinuant
                                •snap:Object
                                        •Molecule
                                                •Protein
                                                        •Membrane_Receptor
                                                                •Neurotransmitter_Receptor
                                                                        •Glutamate_Receptor
                                                                                •NMDA_Receptor

Super Classes

Glutamate_Receptor

Disjoint Classes

AMPA_Receptor

Annotations

birn_annot:curationStatusuncurated
definitionA class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity (MSH).
sao_IDsao794753833
umls_IDC0080093
Generated with OWLDoc