Transmission electron micrograph of isolated HeLa cell metaphase chromosome decondensed by removal of histones with dextran sulfate and heparin, centrifuged onto a carbon film and stained with uranyl acetate. The residual chromosome 'scaffold' is surrounded by extended free DNA loops 20 to 24 micrometers long. Area boxed is shown at higher magnification in the grouped CIL image 11023.
Micrograph from J.R. Paulson and U.K. Laemmli (1977) Cell, 12:817-828, and republished with permission as Figure 130 from Chapter 4 (Nucleus) of 'The Cell' by Don W. Fawcett M.D.
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