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*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:37151*  Cite 

Transmission electron micrograph of cell fractionation of guinea pig pancreas microsomes. Rough microsomes, the cell fractionation equivalent of the rough endoplasmic reticulum with bound ribosomes in intact cells, were extensively used to determine the mechanism of translocation of newly synthesized exportable proteins across the ER membrane. The culmination of these studies on rough microsomes was the elucidation of the "Signal Hypothesis". Image made available by James D. Jamieson and the Department of Cell Biology, Yale University School of Medicine.

Technical Details

Original 3.25 in. x 4 in. lantern slides were scanned at 600dpi. Relevant citations: Siekevitz, P. and G. E. Palade.1958. J. Biochem. Biophys. Cytol. 4:309-318. Palade, G.E., and P. Siekevitz. 1956. J. Biochem. Biophys. Cytol. 2:671-690. Palade. G.E. 1955. J. Biochem. Biophys. Cytol. 1:59-68. Redman, C.M., P. Siekevitz, and G.E. Palade. 1966. J. Biol. Chem. 241:1150-1158. Sabatini, D.D. and G. Blobel. 1970. J. Cell. Biol. 45:146-157.

Biological Sources
NCBI Organism Classification
Cavia porcellus
Cell Type
pancreatic cell
Cellular Component
George E. Palade
Philip Siekevitz
George E. Palade EM Slide Collection
Digital Object Identifier (DOI)
Archival Resource Key (ARK)
Grouping This image is part of a group.
Sample Preparation
cell fractionation
Relation To Intact Cell
sectioned tissue
Spatial Axis Image Size Pixel Size
X 6000px ——
Y 4944px ——