Alternate header for print version


Licensing
Attribution Non-Commercial; No Derivatives:This image is licensed under a Creative Commons Attribution, Non-Commercial, No Derivatives License. View License Deed | View Legal Code
tweet  
*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:38962*  Cite 
Description

Confocal micrograph of teased sciatic nerve fibers. The fibers are triple labelled for neurofilament (blue), S100 (red) and dystrophin-related protein (DRP2) (green). The S100 protein is expressed in the Schwann cells of the peripheral nervous system and in astroglial cells of the central nervous system. DRP2 is thought to be involved in membrane-cytoskeleton interactions at sites of membrane specialization and intercellular contact in various tissues. Disruption of these protein complexes are thought to be a cause of Charcot-Marie-Tooth disease. This is an inherited disease that leads to muscle-wasting.

Technical Details

B0003732 Sciatic nerve fibres. Wellcome Images available under the following creative commons usage http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

Biological Sources
Cell Type
neuron
Cellular Component
neurofilament
S100
dystrophin related protein
Biological Context
Biological Process
sciatic nerve fiber organization
Human Development Anatomy
sciatic nerve
Human Disease
Charcot-Marie-Tooth disease
Attribution
Names
Peter Brophy
Link
Wellcome Images
Citation
Digital Object Identifier (DOI)
doi:10.7295/W9CIL38962
Archival Resource Key (ARK)
ark:/b7295/w9cil38962
Imaging
Image Type
recorded image
Image Mode
confocal microscopy
Parameters Imaged
fluorescence emission
Source of Contrast
distribution of epitope
Visualization Methods
primary antibody plus labeled secondary antibody
Processing History
unprocessed raw data
Sample Preparation
Methods
chemically fixed tissue
Relation To Intact Cell
teased fibers
Dimensions
Spatial Axis Image Size Pixel Size
X 689px ——
Y 576px ——