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Summary Information
Microscopy product ID: 3632
Image basename: CTL_ImmunSynapse
Summary
Project ID
P1694
Leader
Stephen Fuller, Endre Majorovits  (Other projects)
Collaborators
Gillian Griffiths, Jane Stinchcombe, Giovanna Bossi
Project Description
Tomogram of the immunological synapse between a human cytotoxic T lymphocyte (CTL) and a target cell
Experiment Purpose
Defining the structure of the immunological synapse between a human cytotoxic T lymphocyte (CTL) and a target cell and assessing the rearrangement of the microtubule organization center (MTOC) and attached organelles within the CTL during target killing.
Species
human
System
blood
Organ
blood
Region
Cell type
Cytotoxic T Lymphocyte
Structure
CTL immunological synapse
Product Type
DOUBLE TILT
Instrument
FEI Tecnai F30
Publications
Jane C. Stinchcombe, Endre Majorovits, Giovanna Bossi, Stephen Fuller, Gillian M. Griffiths. Centrosome polarization delivers secretory granules to the immunological synapse. Nature 443 (2006) 462-465
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