Electron tomography of mitochondrial adherens complex in the Calyx of Held
Reconstruction of mitochondrial associated adherens complex in the Calyx of Held synapse using electron tomography. The adherens complex is an elaborate cytoskeletal superstructure connecting a subset of mitochondria to the presynaptic membrane near active zones. Note: several additional reconstructions from this project are available from Dr. George Spirou upon request.
Perkins GA, Tjong J, Brown JM, Poquiz PH, Scott RT, Kolson DR, Ellisman MH, Spirou GA. The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism. J Neurosci. 2010 Jan 20;30(3):1015-26. PMID: 20089910